Transfusion instantly deals damage to the enemy before healing Vladimir, making it one of the best last hitting tools in the game.
Cast Hemoplague where it will afflict the most units.
Sanguine Pool pops incoming missiles, so it can be used to dodge disables.
Be wary of team fights while afflicted by Vladimir's Hemoplague.
Making Vladimir use Sanguine Pool at the start of a fight will maximize the Health cost of the ability to him.
Items that counter Health stacking, such as Liandry's Torment and Blade of the Ruined King, are very effective against Vladimir.