Akali excels at killing weaker characters. Let your team initiate and then strike at the people in the back.
Find the balance between storing Essence of Shadows, and using Shadow Dance before having max charges.
Akali can still be hit by area effect spells while Invisible inside Twilight Shroud.
Akali can choose where she starts within her Twilight Shroud before casting it, even if part of the shroud would extend beyond a wall.
Return to base if your Health is low and Akali has multiple charges of her ultimate.