Use Overload's passive to optimize for maximum damage or maximum survivability.
Spell Flux's short cooldown allows it to be used to spread Flux to many enemies.
Ryze can move and cast other spells while Realm Warp is charging without cancelling the portal.
Ryze is especially dangerous to opponents that are marked with Flux.
Use Realm Warp's windup time to figure out how to deal with what may be coming out of the portal.
Crowd controlling Ryze during Realm Warp's windup will cancel the portal.